23
trainings
modules
modules
Science Behind NeuroNation
NeuroNation MED is a product of Synaptikon GmbH located in Berlin (Germany). Since 2011, we have been developing cognitive training and offering the results in NeuroNation.
Our mission at NeuroNation is to combine scientific knowledge with effective adherence methods from app development for evidence-based and personalised cognitive training.
We aim at noticeably improving the lives of our users by providing these exercises. We have initiated more than 20 scientific studies using NeuroNation in the past and some have already been completed with promising results. In this way, we would like to make a contribution to the care of people with cognitive impairments. We are determined to further this initiative in the future.
Our mission at NeuroNation is to combine scientific knowledge with effective adherence methods from app development for evidence-based and personalised cognitive training.
We aim at noticeably improving the lives of our users by providing these exercises. We have initiated more than 20 scientific studies using NeuroNation in the past and some have already been completed with promising results. In this way, we would like to make a contribution to the care of people with cognitive impairments. We are determined to further this initiative in the future.
23
scientific publications
8664
study participants
97%
adherence
NeuroNation MED is a product of Synaptikon GmbH located in Berlin (Germany). Since 2011, we have been developing cognitive training and offering the results in NeuroNation.
Our mission at NeuroNation is to combine scientific knowledge with effective adherence methods from app development for evidence-based and personalised cognitive training.
Our mission at NeuroNation is to combine scientific knowledge with effective adherence methods from app development for evidence-based and personalised cognitive training.
We aim at noticeably improving the lives of our users by providing these exercises. We have initiated more than 20 scientific studies using NeuroNation in the past and some have already been completed with promising results. In this way, we would like to make a contribution to the care of people with cognitive impairments. We are determined to further this initiative in the future.
Developed to the highest standards
Scientifically sound
NeuroNation MED is a CE-approved Class 1 medical device.
Positive treatment results have been confirmed by clinical studies.
Data protection guaranteed
All data is processed in Germany according to European data protection standards and treated confidentially.
What Is NeuroNation?
NeuroNation is a multi-modal cognitive training application for prevention and cognitive enhancement. NeuroNation MED is a CE-marked medical product for personalised cognitive training based on gamified exercises, developed for users with cognitive impairments. Health literacy is conveyed via in-app psycho-education elements and information about brain health. NeuroNation MED is intended to support patients in alleviating the symptoms of mild or moderate, acquired or neurodegenerative cognitive impairments.
Through personalised cognitive exercises the user is able to train global cognition and distinctive domains, including processing speed, reasoning, attention, and working memory. By means of defined cognitive exercises, an individual cognitive profile of the patient is created and personalised cognitive training is tailored to the patient in order to achieve alleviation of cognitive deficits.
Through personalised cognitive exercises the user is able to train global cognition and distinctive domains, including processing speed, reasoning, attention, and working memory. By means of defined cognitive exercises, an individual cognitive profile of the patient is created and personalised cognitive training is tailored to the patient in order to achieve alleviation of cognitive deficits.
Evidence Based
and Used by 25 Million People
and Used by 25 Million People
For 12 years, we have been researching and developing the best possible training. The result is available on www.neuronation.com as well as a mobile app on Android and iOS devices. The app is offered in 10 different languages (German, English, Spanish, Portuguese, Italian, Polish, Korean, Russian, Japanese, and French) used by over 25 million people all over the world. The core function of the training is a personal training plan created based on the cognitive profile of the user. Furthermore, you will find ongoing evaluations and assessments, as well as psycho-educational content, real-life benefits, and exercises to enhance or relax your brain, called NeuroBoosters.
The training was named best "App of the Year" by Apple and by Google and received the Leonardo Award for digital prevention by the German Federal Ministry of Health.
As of May 2023, NeuroNation MED is listed as DiGA in Germany and thus can be prescribed and reimbursed for patients with mild cognitive impairment (ICD-10 F06.7) by all health insurances in Germany.
As of May 2023, NeuroNation MED is listed as DiGA in Germany and thus can be prescribed and reimbursed for patients with mild cognitive impairment (ICD-10 F06.7) by all health insurances in Germany.
DiGA Directory
Best App of the Year
Inclusion in the DiGA Directory by the German Federal Institute for Drugs and Medical Devices
by Apple and Google
AOK Leonardo Award
by the German Federal Ministry of Health and the German Federal Ministry of Education and Research.
Advantages of Cognitive Training With NeuroNation
Highly personalised training plan +
Daily adjusted training +
Easily customizable training experience
Daily adjusted training +
Easily customizable training experience
Comprehensive analysis of strengths and potentials +
Comprehensible display of progress + Detailed evaluation aggregated in domains + Comparison with a peer group
Comprehensible display of progress + Detailed evaluation aggregated in domains + Comparison with a peer group
Regular and customizable training reminders
Gamification - motivating milestones and awards
How Does Cognitive Training With NeuroNation Help?
Completed studies using cognitive training with NeuroNation have collected scientific evidence for the effectiveness of this training program. Here is a list of the most important findings grouped by cognitive domain for alleviating neurocognitive difficulties due to functional disorders of the brain:
Cognitive abilities can be improved
Episodic memory can be improved
Scholl, F., Enge, S., & Gärtner, M. (2021). Commercial Brain Training: Efficacy, Transfer Effects, and the Influence of Personality Traits: A Study Conducted on Healthy Young Adults. Brain Sciences, 11(8), 1083. https://doi.org/10.3390/brainsci11081083
As part of multidisciplinary intervention for Huntington’s patients, verbal learning and memory improved
Bartlett, D. M., Govus, A., Rankin, T., Lampit, A., Feindel, K., Poudel, G., Teo, W.-P., Lo, J., Georgiou-Karistianis, N., Ziman, M. R., & Cruickshank, T. M. (2020). The effects of multidisciplinary rehabilitation on neuroimaging, biological, cognitive and motor outcomes in individuals with premanifest Huntington’s disease. Journal of the Neurological Sciences, 416, 117022. https://doi.org/10.1016/j.jns.2020.117022
Scholl, F., Enge, S., & Gärtner, M. (2021). Commercial Brain Training: Efficacy, Transfer Effects, and the Influence of Personality Traits: A Study Conducted on Healthy Young Adults. Brain Sciences, 11(8), 1083. https://doi.org/10.3390/brainsci11081083
As part of multidisciplinary intervention for Huntington’s patients, verbal learning and memory improved
Bartlett, D. M., Govus, A., Rankin, T., Lampit, A., Feindel, K., Poudel, G., Teo, W.-P., Lo, J., Georgiou-Karistianis, N., Ziman, M. R., & Cruickshank, T. M. (2020). The effects of multidisciplinary rehabilitation on neuroimaging, biological, cognitive and motor outcomes in individuals with premanifest Huntington’s disease. Journal of the Neurological Sciences, 416, 117022. https://doi.org/10.1016/j.jns.2020.117022
Working memory performance can be improved
Visual working memory is increased
Giehl, K., Ophey, A., Reker, P., Rehberg, S., Hammes, J., Barbe, M. T., Zokaei, N., Eggers, C., Husain, M., Kalbe, E., & van Eimeren, T. (2020). Effects of home-based working memory training on visuo-spatial working memory in Parkinson’s Disease: A randomized controlled trial. Journal of Central Nervous System Disease, 12, 117957351989946. https://doi.org/10.1177/1179573519899469
Verbal working memory is increased
Ophey, A., Giehl, K., Rehberg, S., Eggers, C., Reker, P., van Eimeren, T., & Kalbe, E. (2020). Effects of working memory training in patients with Parkinson’s disease without cognitive impairment: A randomized controlled trial. Parkinsonism & Related Disorders, 72, 13–22. https://doi.org/10.1016/j.parkreldis.2020.02.002
Working memory training can lead to neuronal reorganization enhancing neural efficiency
Giehl, K., Ophey, A., Hammes, J., Rehberg, S., Lichtenstein, T., Reker, P., Eggers, C., Kalbe, E., & van Eimeren, T. (2020). Working memory training increases neural efficiency in Parkinson’s disease: A randomized controlled trial. Brain Communications, 2(2), fcaa115. https://doi.org/10.1093/braincomms/fcaa115
Giehl, K., Ophey, A., Reker, P., Rehberg, S., Hammes, J., Barbe, M. T., Zokaei, N., Eggers, C., Husain, M., Kalbe, E., & van Eimeren, T. (2020). Effects of home-based working memory training on visuo-spatial working memory in Parkinson’s Disease: A randomized controlled trial. Journal of Central Nervous System Disease, 12, 117957351989946. https://doi.org/10.1177/1179573519899469
Verbal working memory is increased
Ophey, A., Giehl, K., Rehberg, S., Eggers, C., Reker, P., van Eimeren, T., & Kalbe, E. (2020). Effects of working memory training in patients with Parkinson’s disease without cognitive impairment: A randomized controlled trial. Parkinsonism & Related Disorders, 72, 13–22. https://doi.org/10.1016/j.parkreldis.2020.02.002
Working memory training can lead to neuronal reorganization enhancing neural efficiency
Giehl, K., Ophey, A., Hammes, J., Rehberg, S., Lichtenstein, T., Reker, P., Eggers, C., Kalbe, E., & van Eimeren, T. (2020). Working memory training increases neural efficiency in Parkinson’s disease: A randomized controlled trial. Brain Communications, 2(2), fcaa115. https://doi.org/10.1093/braincomms/fcaa115
Your speed of thinking can be increased
Processing speed improved
Strobach, T., & Huestegge, L. (2017). Evaluating the effectiveness of commercial brain game training with working-memory tasks. Journal of Cognitive Enhancement, 1(4), 539–558. https://doi.org/10.1007/s41465-017-0053-0
As part of multidisciplinary intervention for Huntington’s patients, processing speed improved
Bartlett, D. M., Govus, A., Rankin, T., Lampit, A., Feindel, K., Poudel, G., Teo, W.-P., Lo, J., Georgiou-Karistianis, N., Ziman, M. R., & Cruickshank, T. M. (2020). The effects of multidisciplinary rehabilitation on neuroimaging, biological, cognitive and motor outcomes in individuals with premanifest Huntington’s disease. Journal of the Neurological Sciences, 416, 117022. https://doi.org/10.1016/j.jns.2020.117022
Strobach, T., & Huestegge, L. (2017). Evaluating the effectiveness of commercial brain game training with working-memory tasks. Journal of Cognitive Enhancement, 1(4), 539–558. https://doi.org/10.1007/s41465-017-0053-0
As part of multidisciplinary intervention for Huntington’s patients, processing speed improved
Bartlett, D. M., Govus, A., Rankin, T., Lampit, A., Feindel, K., Poudel, G., Teo, W.-P., Lo, J., Georgiou-Karistianis, N., Ziman, M. R., & Cruickshank, T. M. (2020). The effects of multidisciplinary rehabilitation on neuroimaging, biological, cognitive and motor outcomes in individuals with premanifest Huntington’s disease. Journal of the Neurological Sciences, 416, 117022. https://doi.org/10.1016/j.jns.2020.117022
Attention can be improved
Performance on updating tasks improved
Strobach, T., & Huestegge, L. (2017). Evaluating the effectiveness of commercial brain game training with working-memory tasks. Journal of Cognitive Enhancement, 1(4), 539–558. https://doi.org/10.1007/s41465-017-0053-0
As part of multidisciplinary intervention for Huntington’s patients, dual task performance increased
Reyes, A., Rankin, T., Pulverenti, T. S., Bartlett, D., Georgiou-Karistianis, N., Lampit, A., Ziman, M., & Cruickshank, T. (2021). The effect of multidisciplinary therapy on dual task performance in preclinical Huntington’s disease: An exploratory study. Annals of Physical and Rehabilitation Medicine, 64(4), 101421. https://doi.org/10.1016/j.rehab.2020.06.006
Strobach, T., & Huestegge, L. (2017). Evaluating the effectiveness of commercial brain game training with working-memory tasks. Journal of Cognitive Enhancement, 1(4), 539–558. https://doi.org/10.1007/s41465-017-0053-0
As part of multidisciplinary intervention for Huntington’s patients, dual task performance increased
Reyes, A., Rankin, T., Pulverenti, T. S., Bartlett, D., Georgiou-Karistianis, N., Lampit, A., Ziman, M., & Cruickshank, T. (2021). The effect of multidisciplinary therapy on dual task performance in preclinical Huntington’s disease: An exploratory study. Annals of Physical and Rehabilitation Medicine, 64(4), 101421. https://doi.org/10.1016/j.rehab.2020.06.006
Cognitive performance can be improved
Increasing fitness for everyday life and reduced cognitive error rate (subjective evaluation in Cognitive Failures Questionnaire (CFQ))
Strobach, T., & Huestegge, L. (2017). Evaluating the effectiveness of commercial brain game training with working-memory tasks. Journal of Cognitive Enhancement, 1(4), 539–558. https://doi.org/10.1007/s41465-017-0053-0
Strobach, T., & Huestegge, L. (2017). Evaluating the effectiveness of commercial brain game training with working-memory tasks. Journal of Cognitive Enhancement, 1(4), 539–558. https://doi.org/10.1007/s41465-017-0053-0
Scientific Evidence
Besides validating the tasks and exercises in NeuroNation, most studies have and are continuing to focus on providing scientific evidence on the effectiveness of our training program.
Grouped by study participants, here is a list of ongoing and past studies with NeuroNation.
Grouped by study participants, here is a list of ongoing and past studies with NeuroNation.
2 studies
2 studies
4 studies
5 studies
4 studies
1 study
1 study
1 study
Studies: Cognitive Aging
AgeWell.de
AgeWell.de – a pragmatic multi-centre cluster-randomized controlled prevention trial against cognitive decline in older primary care patients
Study completed – results are currently prepared for scientific publication.
Zülke, A., Luck, T., Pabst, A., Hoffmann, W., Thyrian, J. R., Gensichen, J., Kaduszkiewicz, H., König, H.-H., Haefeli, W. E., Czock, D., Wiese, B., Frese, T., Röhr, S., & Riedel-Heller, S. G. (2019). AgeWell.de – study protocol of a pragmatic multi-center cluster-randomized controlled prevention trial against cognitive decline in older primary care patients. BMC Geriatrics, 19(1), 203. https://doi.org/10.1186/s12877-019-1212-1
Röhr, S., Zülke, A., Luppa, M., Brettschneider, C., Weißenborn, M., Kühne, F., Zöllinger, I., Samos, F.-A. Z., Bauer, A., Döhring, J., Krebs-Hein, K., Oey, A., Czock, D., Frese, T., Gensichen, J., Haefeli, W. E., Hoffmann, W., Kaduszkiewicz, H., König, H.-H., … Riedel-Heller, S. G. (2021). Recruitment and Baseline Characteristics of Participants in the AgeWell.de Study—A Pragmatic Cluster-Randomized Controlled Lifestyle Trial against Cognitive Decline. International Journal of Environmental Research and Public Health, 18(2), 408. https://doi.org/10.3390/ijerph18020408
Maintain Your Brain
Maintain Your Brain (MYB) is a randomized controlled trial of an online multi-modal lifestyle intervention targeting modifiable dementia risk factors with its primary aim being to reduce cognitive decline in an older age cohort.
Study completed - results are currently prepared for scientific publication.
Heffernan, M., Andrews, G., Fiatarone Singh, M. A., Valenzuela, M., Anstey, K. J., Maeder, A. J., McNeil, J., Jorm, L., Lautenschlager, N. T., Sachdev, P. S., Ginige, J. A., Hobbs, M. J., Boulamatsis, C., Chau, T., Cobiac, L., Cox, K. L., Daniel, K., Flood, V. M., Guerrero, Y., … Brodaty, H. (2019). Maintain Your Brain: Protocol of a 3-Year Randomized Controlled Trial of a Personalized Multi-Modal Digital Health Intervention to Prevent Cognitive Decline Among Community Dwelling 55 to 77 Year Olds. Journal of Alzheimer’s Disease, 70(s1), S221–S237. https://doi.org/10.3233/JAD-180572
Walton, C. C., Lampit, A., Boulamatsis, C., Hallock, H., Barr, P., Ginige, J. A., Brodaty, H., Chau, T., Heffernan, M., Sachdev, P. S., Fiatarone Singh, M. A., & Valenzuela, M. (2019). Design and development of the brain training system for the digital “Maintain Your Brain” dementia prevention trial. JMIR Aging, 2(1), e13135. https://doi.org/10.2196/13135
AgeWell.de – a pragmatic multi-centre cluster-randomized controlled prevention trial against cognitive decline in older primary care patients
Study completed – results are currently prepared for scientific publication.
Zülke, A., Luck, T., Pabst, A., Hoffmann, W., Thyrian, J. R., Gensichen, J., Kaduszkiewicz, H., König, H.-H., Haefeli, W. E., Czock, D., Wiese, B., Frese, T., Röhr, S., & Riedel-Heller, S. G. (2019). AgeWell.de – study protocol of a pragmatic multi-center cluster-randomized controlled prevention trial against cognitive decline in older primary care patients. BMC Geriatrics, 19(1), 203. https://doi.org/10.1186/s12877-019-1212-1
Röhr, S., Zülke, A., Luppa, M., Brettschneider, C., Weißenborn, M., Kühne, F., Zöllinger, I., Samos, F.-A. Z., Bauer, A., Döhring, J., Krebs-Hein, K., Oey, A., Czock, D., Frese, T., Gensichen, J., Haefeli, W. E., Hoffmann, W., Kaduszkiewicz, H., König, H.-H., … Riedel-Heller, S. G. (2021). Recruitment and Baseline Characteristics of Participants in the AgeWell.de Study—A Pragmatic Cluster-Randomized Controlled Lifestyle Trial against Cognitive Decline. International Journal of Environmental Research and Public Health, 18(2), 408. https://doi.org/10.3390/ijerph18020408
Maintain Your Brain
Maintain Your Brain (MYB) is a randomized controlled trial of an online multi-modal lifestyle intervention targeting modifiable dementia risk factors with its primary aim being to reduce cognitive decline in an older age cohort.
Study completed - results are currently prepared for scientific publication.
Heffernan, M., Andrews, G., Fiatarone Singh, M. A., Valenzuela, M., Anstey, K. J., Maeder, A. J., McNeil, J., Jorm, L., Lautenschlager, N. T., Sachdev, P. S., Ginige, J. A., Hobbs, M. J., Boulamatsis, C., Chau, T., Cobiac, L., Cox, K. L., Daniel, K., Flood, V. M., Guerrero, Y., … Brodaty, H. (2019). Maintain Your Brain: Protocol of a 3-Year Randomized Controlled Trial of a Personalized Multi-Modal Digital Health Intervention to Prevent Cognitive Decline Among Community Dwelling 55 to 77 Year Olds. Journal of Alzheimer’s Disease, 70(s1), S221–S237. https://doi.org/10.3233/JAD-180572
Walton, C. C., Lampit, A., Boulamatsis, C., Hallock, H., Barr, P., Ginige, J. A., Brodaty, H., Chau, T., Heffernan, M., Sachdev, P. S., Fiatarone Singh, M. A., & Valenzuela, M. (2019). Design and development of the brain training system for the digital “Maintain Your Brain” dementia prevention trial. JMIR Aging, 2(1), e13135. https://doi.org/10.2196/13135
Studies: Prevention
PFIFF
Evaluation of a program to support and retain intellectual abilities of older workers.
Gajewski, P. D., & Falkenstein, M. (2011). Neurocognition of aging in working environments. Zeitschrift Für ArbeitsmarktForschung, 44(4), 307–320. https://doi.org/10.1007/s12651-011-0090-6
Stahn, C. (2011). Evaluation einer Interventionsmaßnahme zur Steigerung der kognitiven Leistungsfähigkeit bei älteren Arbeitnehmern in der Automobilbranche. https://doi.org/10.17877/DE290R-3215
Evaluation of a program to support and retain intellectual abilities of older workers.
Gajewski, P. D., & Falkenstein, M. (2011). Neurocognition of aging in working environments. Zeitschrift Für ArbeitsmarktForschung, 44(4), 307–320. https://doi.org/10.1007/s12651-011-0090-6
Stahn, C. (2011). Evaluation einer Interventionsmaßnahme zur Steigerung der kognitiven Leistungsfähigkeit bei älteren Arbeitnehmern in der Automobilbranche. https://doi.org/10.17877/DE290R-3215
Studies: Huntington’s Disease
Edith Cowan University
In this pilot study, patients with Huntington’s Disease were treated with a multidisciplinary intervention.
Trial registration of follow-up study: https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=377450&isReview=true
Bartlett, D. M., Govus, A., Rankin, T., Lampit, A., Feindel, K., Poudel, G., Teo, W.-P., Lo, J., Georgiou-Karistianis, N., Ziman, M. R., & Cruickshank, T. M. (2020). The effects of multidisciplinary rehabilitation on neuroimaging, biological, cognitive and motor outcomes in individuals with premanifest Huntington’s disease. Journal of the Neurological Sciences, 416, 117022. https://doi.org/10.1016/j.jns.2020.117022
Bartlett, D. M., Poudel, G., Maddison, K. J., Lampit, A., Dann, L., Eastwood, P. R., Lazar, A. S., Ziman, M. R., & Cruickshank, T. M. (2020). Effect of multidisciplinary rehabilitation on sleep outcomes in individuals with preclinical Huntington disease: An exploratory study. Annals of Physical and Rehabilitation Medicine, 63(6), 570–573. https://doi.org/10.1016/j.rehab.2019.11.003
Bartlett, D. M., Dominguez D, J. F., Lazar, A. S., Kordsachia, C. C., Rankin, T. J., Lo, J., Govus, A. D., Power, B. D., Lampit, A., Eastwood, P. R., Ziman, M. R., & Cruickshank, T. M. (2020). Multidisciplinary rehabilitation reduces hypothalamic grey matter volume loss in individuals with preclinical Huntington’s disease: A nine-month pilot study. Journal of the Neurological Sciences, 408, 116522. https://doi.org/10.1016/j.jns.2019.116522
Reyes, A., Rankin, T., Pulverenti, T. S., Bartlett, D., Georgiou-Karistianis, N., Lampit, A., Ziman, M., & Cruickshank, T. (2021). The effect of multidisciplinary therapy on dual task performance in preclinical Huntington’s disease: An exploratory study. Annals of Physical and Rehabilitation Medicine, 64(4), 101421. https://doi.org/10.1016/j.rehab.2020.06.006
In this pilot study, patients with Huntington’s Disease were treated with a multidisciplinary intervention.
Trial registration of follow-up study: https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=377450&isReview=true
Bartlett, D. M., Govus, A., Rankin, T., Lampit, A., Feindel, K., Poudel, G., Teo, W.-P., Lo, J., Georgiou-Karistianis, N., Ziman, M. R., & Cruickshank, T. M. (2020). The effects of multidisciplinary rehabilitation on neuroimaging, biological, cognitive and motor outcomes in individuals with premanifest Huntington’s disease. Journal of the Neurological Sciences, 416, 117022. https://doi.org/10.1016/j.jns.2020.117022
Bartlett, D. M., Poudel, G., Maddison, K. J., Lampit, A., Dann, L., Eastwood, P. R., Lazar, A. S., Ziman, M. R., & Cruickshank, T. M. (2020). Effect of multidisciplinary rehabilitation on sleep outcomes in individuals with preclinical Huntington disease: An exploratory study. Annals of Physical and Rehabilitation Medicine, 63(6), 570–573. https://doi.org/10.1016/j.rehab.2019.11.003
Bartlett, D. M., Dominguez D, J. F., Lazar, A. S., Kordsachia, C. C., Rankin, T. J., Lo, J., Govus, A. D., Power, B. D., Lampit, A., Eastwood, P. R., Ziman, M. R., & Cruickshank, T. M. (2020). Multidisciplinary rehabilitation reduces hypothalamic grey matter volume loss in individuals with preclinical Huntington’s disease: A nine-month pilot study. Journal of the Neurological Sciences, 408, 116522. https://doi.org/10.1016/j.jns.2019.116522
Reyes, A., Rankin, T., Pulverenti, T. S., Bartlett, D., Georgiou-Karistianis, N., Lampit, A., Ziman, M., & Cruickshank, T. (2021). The effect of multidisciplinary therapy on dual task performance in preclinical Huntington’s disease: An exploratory study. Annals of Physical and Rehabilitation Medicine, 64(4), 101421. https://doi.org/10.1016/j.rehab.2020.06.006
Studies: Parkinson’s
Hertie Institut
This study by UKSH, Campus Kiel, studied if the progression of Parkinson’s can be slowed down by different interventions.
Study completed - results are currently prepared for scientific publication.
University Hospital Cologne
Computerised working memory training in Parkinson's disease patients without cognitive impairment: Cognitive and neural effects and prediction of training outcome
Giehl, K., Ophey, A., Reker, P., Rehberg, S., Hammes, J., Barbe, M. T., Zokaei, N., Eggers, C., Husain, M., Kalbe, E., & van Eimeren, T. (2020). Effects of home-based working memory training on visuo-spatial working memory in Parkinson’s Disease: A randomized controlled trial. Journal of Central Nervous System Disease, 12, 117957351989946. https://doi.org/10.1177/1179573519899469
Ophey, A., Giehl, K., Rehberg, S., Eggers, C., Reker, P., van Eimeren, T., & Kalbe, E. (2020). Effects of working memory training in patients with Parkinson’s disease without cognitive impairment: A randomized controlled trial. Parkinsonism & Related Disorders, 72, 13–22. https://doi.org/10.1016/j.parkreldis.2020.02.002
Ophey, A., Wenzel, J., Paul, R., Giehl, K., Rehberg, S., Eggers, C., Reker, P., van Eimeren, T., Kalbe, E., & Kambeitz-Ilankovic, L. (2022). Cognitive performance and learning parameters predict response to working memory training in Parkinson’s disease. Journal of Parkinson’s Disease, 12(7), 2235–2247. https://doi.org/10.3233/JPD-223448
Ophey, A., Rehberg, S., Giehl, K., Eggers, C., Reker, P., van Eimeren, T., & Kalbe, E. (2021). Predicting working memory training responsiveness in Parkinson’s disease: Both “system hardware” and room for improvement are needed. Neurorehabilitation and Neural Repair, 35(2), 117–130. https://doi.org/10.1177/1545968320981956
Giehl, K., Ophey, A., Hammes, J., Rehberg, S., Lichtenstein, T., Reker, P., Eggers, C., Kalbe, E., & van Eimeren, T. (2020). Working memory training increases neural efficiency in Parkinson’s disease: A randomized controlled trial. Brain Communications, 2(2), fcaa115. https://doi.org/10.1093/braincomms/fcaa115
This study by UKSH, Campus Kiel, studied if the progression of Parkinson’s can be slowed down by different interventions.
Study completed - results are currently prepared for scientific publication.
University Hospital Cologne
Computerised working memory training in Parkinson's disease patients without cognitive impairment: Cognitive and neural effects and prediction of training outcome
Giehl, K., Ophey, A., Reker, P., Rehberg, S., Hammes, J., Barbe, M. T., Zokaei, N., Eggers, C., Husain, M., Kalbe, E., & van Eimeren, T. (2020). Effects of home-based working memory training on visuo-spatial working memory in Parkinson’s Disease: A randomized controlled trial. Journal of Central Nervous System Disease, 12, 117957351989946. https://doi.org/10.1177/1179573519899469
Ophey, A., Giehl, K., Rehberg, S., Eggers, C., Reker, P., van Eimeren, T., & Kalbe, E. (2020). Effects of working memory training in patients with Parkinson’s disease without cognitive impairment: A randomized controlled trial. Parkinsonism & Related Disorders, 72, 13–22. https://doi.org/10.1016/j.parkreldis.2020.02.002
Ophey, A., Wenzel, J., Paul, R., Giehl, K., Rehberg, S., Eggers, C., Reker, P., van Eimeren, T., Kalbe, E., & Kambeitz-Ilankovic, L. (2022). Cognitive performance and learning parameters predict response to working memory training in Parkinson’s disease. Journal of Parkinson’s Disease, 12(7), 2235–2247. https://doi.org/10.3233/JPD-223448
Ophey, A., Rehberg, S., Giehl, K., Eggers, C., Reker, P., van Eimeren, T., & Kalbe, E. (2021). Predicting working memory training responsiveness in Parkinson’s disease: Both “system hardware” and room for improvement are needed. Neurorehabilitation and Neural Repair, 35(2), 117–130. https://doi.org/10.1177/1545968320981956
Giehl, K., Ophey, A., Hammes, J., Rehberg, S., Lichtenstein, T., Reker, P., Eggers, C., Kalbe, E., & van Eimeren, T. (2020). Working memory training increases neural efficiency in Parkinson’s disease: A randomized controlled trial. Brain Communications, 2(2), fcaa115. https://doi.org/10.1093/braincomms/fcaa115
Studies: MCI & Dementia
MCI-TRAM - University Hospital Jena
Effectiveness of cognitive training on attention and memory performance of patients with mild cognitive impairment.
Study completed - results are currently prepared for scientific publication.
SEPSIS - STARDUsT - University Hospital Jena
Stratifying and treating sepsis-associated cognitive dysfunction - STARDUST
Study completed - results are currently prepared for scientific publication.
Efficacy trial F06.7 - Charité, University Hospital Jena, University Hospital Cologne, LUX, LMU Munich
Evaluating efficacy of cognitive training in patients with mild cognitive disorder.
Trial registration: https://drks.de/search/de/trial/DRKS00025133
Preliminary results published in DiGA directory: https://diga.bfarm.de/de/verzeichnis/01113
Study is currently recruiting.
Studies: Multiple Sclerosis
Brain Rehabilitation Assessment and InterventioN (BRAIN): Delivering Efficacious Training at Home
[Logo: Charité]
Computerized cognitive training is an efficacious strategy for cognitive impairment across the lifespan and neurodegenerative disorders, a pressing and unmet public health challenge. Yet efficacy is strongly related to key intervention design factors, and we currently do not have the tools to deliver clinical-grade cognitive training at scale. BRAIN, a digital diagnostic and rehabilitation tool, aims to close this implementation gap by facilitating remote clinician-led assessment, training monitoring of cognitive performance using novel personalisation and communication solutions.
Hallock, H., Lampit, A., Kuchling, J., & Finke, C. (2019). Brain Rehabilitation Assessment and InterventioN (BRAIN): Delivering efficacious training at home. 2019 International Conference on Virtual Rehabilitation (ICVR), 1–2. https://doi.org/10.1109/ICVR46560.2019.8994748
[Logo: Charité]
Computerized cognitive training is an efficacious strategy for cognitive impairment across the lifespan and neurodegenerative disorders, a pressing and unmet public health challenge. Yet efficacy is strongly related to key intervention design factors, and we currently do not have the tools to deliver clinical-grade cognitive training at scale. BRAIN, a digital diagnostic and rehabilitation tool, aims to close this implementation gap by facilitating remote clinician-led assessment, training monitoring of cognitive performance using novel personalisation and communication solutions.
Hallock, H., Lampit, A., Kuchling, J., & Finke, C. (2019). Brain Rehabilitation Assessment and InterventioN (BRAIN): Delivering efficacious training at home. 2019 International Conference on Virtual Rehabilitation (ICVR), 1–2. https://doi.org/10.1109/ICVR46560.2019.8994748
Studies: ADHD
LVR-Klinikum Essen
Evaluating efficacy of cognitive training in adult patients with ADHD.
Study is in preparation.
University Hospital Bonn
Evaluating efficacy of cognitive training in adult patients with ADHD.
Trial registration: https://drks.de/search/de/trial/DRKS00030767
Study is currently recruiting.
Evaluating efficacy of cognitive training in adult patients with ADHD.
Study is in preparation.
University Hospital Bonn
Evaluating efficacy of cognitive training in adult patients with ADHD.
Trial registration: https://drks.de/search/de/trial/DRKS00030767
Study is currently recruiting.
Studies: Concussion
KOGTIG - Charité
Feasibility study with athletes at risk of sport-related concussions.
https://www.bisp-surf.de/Record/PU202210007280
Research Validating Our NeuroNation Tasks
Our conceptualization of scientific tasks in the exercises in NeuroNation have been validated in the following publications:
Johann, V. E., & Karbach, J. (2020). Effects of game‐based and standard executive control training on cognitive and academic abilities in elementary school children. Developmental Science, 23(4). https://doi.org/10.1111/desc.12866
Mack, M., Stojan, R., Bock, O., & Voelcker-Rehage, C. (2022). Cognitive-motor multitasking in older adults: A randomized controlled study on the effects of individual differences on training success. BMC Geriatrics, 22(1), 581. https://doi.org/10.1186/s12877-022-03201-5
Niedeggen, M., Gerlach, L., & Leithäuser, G. (2012). Transfer effects of cognitive training based on working memory tasks. Abstracts zur 27. Jahrestagung der Gesellschaft für Neuropsychologie 2012, 20.–22. September 2012 in Marburg. https://doi.org/10.1024/1016-264X/a000071
Scholl, F., Enge, S., & Gärtner, M. (2021). Commercial Brain Training: Efficacy, Transfer Effects, and the Influence of Personality Traits: A Study Conducted on Healthy Young Adults. Brain Sciences, 11(8), 1083. https://doi.org/10.3390/brainsci11081083
Strobach, T., & Huestegge, L. (2017). Evaluating the effectiveness of commercial brain game training with working-memory tasks. Journal of Cognitive Enhancement, 1(4), 539–558. https://doi.org/10.1007/s41465-017-0053-0
Johann, V. E., & Karbach, J. (2020). Effects of game‐based and standard executive control training on cognitive and academic abilities in elementary school children. Developmental Science, 23(4). https://doi.org/10.1111/desc.12866
Mack, M., Stojan, R., Bock, O., & Voelcker-Rehage, C. (2022). Cognitive-motor multitasking in older adults: A randomized controlled study on the effects of individual differences on training success. BMC Geriatrics, 22(1), 581. https://doi.org/10.1186/s12877-022-03201-5
Niedeggen, M., Gerlach, L., & Leithäuser, G. (2012). Transfer effects of cognitive training based on working memory tasks. Abstracts zur 27. Jahrestagung der Gesellschaft für Neuropsychologie 2012, 20.–22. September 2012 in Marburg. https://doi.org/10.1024/1016-264X/a000071
Scholl, F., Enge, S., & Gärtner, M. (2021). Commercial Brain Training: Efficacy, Transfer Effects, and the Influence of Personality Traits: A Study Conducted on Healthy Young Adults. Brain Sciences, 11(8), 1083. https://doi.org/10.3390/brainsci11081083
Strobach, T., & Huestegge, L. (2017). Evaluating the effectiveness of commercial brain game training with working-memory tasks. Journal of Cognitive Enhancement, 1(4), 539–558. https://doi.org/10.1007/s41465-017-0053-0
Research Collaborations
At NeuroNation, we believe that digital cognitive training, made simple and available to all, even at home, is the most promising path to improved cognitive health. We believe that scientific results and continuous improvements in training are the key to success in this regard.
For this reason, we have launched the NeuroNation Science Hub as a platform where scientists from the fields of cognitive neuroscience and neuropsychology who work with patients with cognitive impairment or who are at increased risk for it can network, collaborate and learn from each other.
Our platform aims to help both the scientific and clinical sides of this by connecting brilliant minds and research ideas with clinical need and patient access.
For this reason, we have launched the NeuroNation Science Hub as a platform where scientists from the fields of cognitive neuroscience and neuropsychology who work with patients with cognitive impairment or who are at increased risk for it can network, collaborate and learn from each other.
Our platform aims to help both the scientific and clinical sides of this by connecting brilliant minds and research ideas with clinical need and patient access.
- Networking with other scientific partners to increase the visibility of one's own work and to initiate new collaborations
- Presentation of own research to an interested scientific and medical audience
- Networking and clinical partnerships to accelerate patient recruitment
- Use of our database of interested subjects to quickly reach a broad pool of potential participants
- Analysis of anonymized training data and recruitment opportunities from over 25 million users of NeuroNation's cognitive training (worldwide)
- Make cognitive training available to your patients by networking with scientific partners and recruiting for ongoing studies
- Increase the visibility of current clinical needs related to cognitive training and find a scientific collaboration to work on a solution
- Staying abreast of the latest research on cognitive training
- Collaborate on scientific studies with a minimum of effort beyond the clinical setting
Application as a possible study participant
If you are interested in participating in current research on cognitive training, you can register here without obligation. We will present you with suitable studies in the NeuroNation Science Hub where you can sign up as a participant or you can be contacted by researchers about new studies. All information is voluntary, of course, but the more completely you fill out your profile, the better the selection of studies will be that are offered to you. Of course, you can also delete your data at any time without giving reasons.
Design Principles Behind NeuroNation MED
All of the assessments and training tasks in NeuroNation and NeuroNation MED are constructed starting from a scientific background. Research in cognitive neuroscience and neuropsychology has been exploring a plethora of possibilities on how to train cognitive abilities. Some of these tasks are very well known within the scientific community for their association with a certain set of cognitive abilities that are needed to solve them.
But cognitive testing or training with these “naked” scientific tasks might get a little boring over time. So we took up the basic ideas and molded them into gamified and personalised versions. The design principles behind our tasks are therefore:
Start with a scientifically proven task
Apply an attractive yet clear design
Add gamification elements
Fine-tune possibilities for personalisation in difficulty
Explanation of tasks that are easy to understand and remember
Continuous improvement of the balance and personalisation of the exercises to increase the effectiveness
Scientific Background of Our NeuroNation MED Tasks
